Sounds like your doing 2D router work (4x8 sheet) I dont think nesting supports solids.
If your making a million copies of a solid to fill a 4x8 sheet, that's probably a problem also.
If your doing 2D router work, just use the wireframe and make a million copies of that. A LOT less overhead. I know Mastercam is supposed to be a big robust CadCam package. But its really a CAM package. If the CAd stuff gets to be too much it can be a problem.
Think if it like this... I can carry a bucket of water. I can carry 2 buckets of water. I might be able to carry 3 buckets of water. But if you want to carry 12 buckets of water, somethings got to give.
And nesting is actually pretty cool and works pretty well. It is free in X4 (might be MU1).
Mike Mattera
Tips For Manufacturing Training CD's, DVD's for Mastercam, SolidWorks, Inventor, G-Code Training & More
http://www.tipsforcadcam.com