This is NOT my quote.
G53 is much easier to understand and use. It is a simple motion command, like G00 or G01, but with G53, the origin for the motion is the machine’s zero return position and the motion will occur at rapid. Here is the command to rapid the Z axis to the zero return position:
G53 Z0
As you might expect, most programmers that understand both methods prefer G53 over G28. However, G53 hasn’t been around as long as G28. Additionally, some machine tool builders never made G53 part of their standard package of G codes when they bought controls from FANUC. This means you may have machines that do not allow G53 (without purchasing G53 from FANUC). Even though G53 may be better, G28 is more universal. If you want to use one method that will work on all machines, you may be stuck with G28.
One more advantage of G53 is that the zero return position does not have to be the destination point. Consider, for example, how you position a turning center’s turret to a safe index position prior to a turret index. You may determine, for example, that the safe index position is at the zero return position in X but 8 inches from the zero return position in Z (closer to the chuck/workpiece). This command will send the X and Z axes directly to the safe index position:
G53 X0 Z-8.0
Remember that the origin for G53 is the zero return position, and since the zero return position is usually at the extreme plus end of each axis, commanded positions will almost always be negative.
This technique can also be helpful with machining centers that have pallet changers and when the pallet change position is a precise distance from the zero return position in one or more axes. For a machine with which the pallet change position is at the zero return position in X but 4 inches away from the zero return position in Y, this command sends the machine to its pallet change position:
G53 X0 Y-4.0
The G53 command has its advantages over G28, but both can be used to get machine axes on FANUC-controlled machines back to the zero return position when required.
It's a great read from...
G28 Versus G53 : Modern Machine Shop
I've read it a dozen times, I found it worth reading.
Luck.