In my experience my issues have been with the extruder barrel itself becoming flimsy as it heats up. I am sure I am too blame with the more is better approach (heat control :-)). Using the slicer software the Z speed does not really come into play as all Z moves are done only after all X & Y moves at that level are finished. I was able to do some ok printing on my A2Z RepStrap. I will get back to it again most likely with a modified extruder using all metal connections for support of the tip. Fins and fans whatever to eliminate that PEEK tube. Otherwise I don't see any reason an existing mill can't be used. In fact when I have seen 3D printers in action their speeds weren't overly impressive. Theoretically the machine might be capable of high speeds but the printing speed itself is much lower.
A lazy man does it twice.