We do mostly nylon and polypropylene material wise, but I assume it will cut very similar to Delrin will. With the O-Flute cutters I can plunge straight into the material and not have to peck like I do with a drill because of wrapping and having the material fuse to the drill bits. Also I do a ton of counter bored holes, so I plunge in the middle to full depth, then move back up and move out and interpolate a circle to make the c-bore all in one step while in the hole location. This ends up being way faster than changing tools and coming back through and spot facing for me. I highly reccomend getting one if your into cutting plastic.
Here is a link to their catalog
http://www.onsrud.com/files/pdf/OC-1...oolCatalog.pdf